Article
Association study of angiotensin-converting enzyme gene polymorphism with schizophrenia and polydipsia.
Neuropsychobiology - 1 Jan 2001
Ouyang W C, Wang Y C, Hong C J, Cheng C Y, Tsai S J
Abstract excerpt
Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. Previous studies have revealed changes in the central ACE levels for schizophrenic patients, possibly related to the polydipsia commonly demonstrated for chronic schizophrenia. An insertion (I)/deletion (D) polymorphism of the ACE gene has been associated with ACE levels....
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