Indoles as gut microbial pharmaco-metabolites : targets, mechanisms and consequences for obesity and cardiometabolic diseases

Abstract excerpt

The gut microbiota play a pivotal role in the onset and development of obesity and cardiometabolic disorders. Obese subjects exhibit significant gut microbial changes, including enrichment for bacterial genes associated with the degradation of tryptophan, which is converted by gut bacteria into indoles. Indoles act as signalling molecules in the microbial-mammalian crosstalk; however, their human targets and mecha...

Topics

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• Clostridium difficile and Clostridium perfringens research
• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Gastrointestinal motility and disorders
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment
• Probiotics and Fermented Foods
• Tryptophan and brain disorders

Identifiers and source

Literature Corpus work

ffefdba5-895b-5305-a3c6-349518a3af54

DOI

10.25560/58098