Article

Relevance of aldehydes in understanding gene-drug interactions and cancer subpopulations

2020-01-01

Abstract excerpt

Aldehyde dehydrogenase (ALDH) enzymes are key for the metabolism and detoxification of aldehydes and biosynthesis of molecules critical for cellular function. ALDHs are highly expressed in stem cells and are considered reliable experimental markers of cancer initiating cells. ALDHs are key enzymes for the bioactivation of 5-nitrofurans (5-NFNs) but downstream effects of this interaction on ALDH-mediated metabolic...

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Literature Corpus work: ffb80b2f-1b9e-575c-b7c6-d47561c08ca6
DOI: 10.7488/era/299

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