Article

AI-Driven CRISPR-Cas9 sgRNA Design for PDCD1, TRAC, and B2M Knockout to Improve CAR T Cell Therapy

2025-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> CRISPR-Cas9 technology is a powerful tool for precise genome editing and is increasingly applied to correct genetic mutations associated with various diseases, including cancer. This system utilizes a single-guide RNA (sgRNA), typically 20 base pairs long and complementary to the target DNA sequence, to direct the Cas9 nuclease for targeted gene activation (knoc...

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Literature Corpus work: ffa5db02-3aec-5854-8463-e197c1726f88
DOI: 10.21203/rs.3.rs-6596407/v1

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