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Article

p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic Control Genes

25 May 2012

Abstract excerpt

It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems. To investigate the roles of p21 in transcriptional control, we studied the gene expression changes in two human cell systems. Using a human leukemia cell line (K562) with inducible p21 expression and human primary keratinocytes with adenoviral-mediated p21 expression, we...

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PMID: 22662213
DOI: 10.1371/journal.pone.0037759

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