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Article

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics.

Genome biology - 15 Jan 2024

Cooper Sarah E, Coelho Matthew A, Strauss Magdalena E, Gontarczyk Aleksander M, Wu Qianxin, Garnett Mathew J, Marioni John C, Bassett Andrew R

Abstract excerpt

CRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand the effect of genetic perturbations including single nucleotide variants (SNVs) associated with diseases. Interpretation of these data is currently limited as genotypes cannot be accurately inferred from guide RNA identity alone. scSNV-seq overcomes this limitation by coupling single-cell genotyping and transcriptomics of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38225637
DOI: 10.1186/s13059-024-03169-y
PMCID: PMC10789043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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