Article

Development of LYTACs via incorporating a nucleolin-targeting and lysosome-directed aptamer

2025-09-02

Abstract excerpt

Lysosomal targeting chimeras (LYTACs) represent an emerging class of bifunctional molecules that bridge extracellular target proteins with intrinsic lysosome-targeting receptors (LTRs) on the cell surface, facilitating endocytic internalization and subsequent lysosomal degradation of the targets. However, the therapeutic potential of LYTACs has been limited by the scarcity of suitable intrinsic LTRs. We previously...

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Literature Corpus work: ff4ffcd1-50d9-5448-9c54-f74d69d2573a
DOI: 10.1101/2025.08.29.672993

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