Article

Directed Evolution of Genetically Encoded LYTACs for Cell-Mediated Delivery

2023-11-15

Abstract excerpt

Lysosome-targeting chimeras (LYTACs) are a promising therapeutic modality to drive the degradation of extracellular proteins. However, early versions of LYTAC contain synthetic glycopeptides that cannot be genetically encoded. Here we present our designs for a fully genetically encodable LYTAC (GELYTAC), making our tool compatible with integration into therapeutic cells for targeted delivery at diseased sites. To...

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Literature Corpus work: d3b86013-5043-5ac7-a589-6113281c4ae2
DOI: 10.1101/2023.11.14.567117

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