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Liver-targeting chimeras as a potential modality for the treatment of liver diseases

2 Sept 2024

Abstract excerpt

Liver diseases pose significant challenges to global public health. In the realm of drug discovery and development, overcoming 'on-target off-tissue' effects remains a substantial barrier for various diseases. In this study, we have pioneered a Liver-Targeting Chimera (LIVTAC) approach using a proteolysis-targeting chimera (PROTAC) molecule coupled to the liver-specific asialoglycoprotein receptor (ASGPR) through...

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PMID: 39208934
DOI: 10.1016/j.jconrel.2024.08.044

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