Article

Short-term high fat diet feeding of mice suppresses catecholamine-stimulated Ca <sup>2+</sup> signalling in hepatocytes and intact liver

2022-08-28

Abstract excerpt

Excess consumption of carbohydrates, fat, and calories leads to non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance; major factors in the pathogenesis of type II diabetes. Hormones and catecholamines acting through G-protein coupled receptors (GPCRs) linked to phospholipase C (PLC) and increases in cytosolic Ca 2+ ([Ca 2+ ] c ) regulate many metabolic functions of the liver. In the intact l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff436b56-a5a0-52ce-81c5-e330d74bff49
DOI: 10.1101/2022.08.28.505514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Short-term high fat diet feeding of mice suppresses catecholamine-stimulated Ca <sup>2+</sup> signalling in hepatocytes and intact liverDOI 10.1101/2022.08.28.505514Read

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesSemantic proximity Read

Early changes of ER-mitochondrial interaction in the liver of high-fat diet-fed miceSemantic proximity Read

Dietary Amino Acids Promote Glucagon-like Hormone Release to Generate Novel Calcium Waves in Adipose TissuesSemantic proximity Read

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clockSemantic proximity Read

Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.Semantic proximity Read

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.Semantic proximity Read

Neuronal Lipoprotein Lipase Deficiency alters Neuronal Function and Hepatic MetabolismSemantic proximity Read

A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.Semantic proximity Read

CYCLIC FEEDING REGIME MAY DELAY AGING IN ANIMALS BY ENHANCING THE HEPATOCYTES NUCLEI STRUCTURESemantic proximity Read

Pathophysiology of impaired pulsatile insulin release.Semantic proximity Read

A novel S1PR4 functional antagonist prevents nonalcoholic steatohepatitis by deactivating the NLRP3 inflammasome without causing lymphopeniaSemantic proximity Read