Article

Oncogenic Gene Fusions in Non-Neoplastic Precursors as Evidence that Bacterial Infection Initiates Prostate Cancer

2020-07-28

Abstract excerpt

Prostate adenocarcinoma is the second most commonly diagnosed cancer in men worldwide and the initiating factors are unknown. Oncogenic TMPRSS2:ERG (ERG+) gene fusions are facilitated by DNA breaks and occur in up to 50% of prostate cancers 1,2 . Infection-driven inflammation is implicated in the formation of ERG+ fusions 3 , and we hypothesized that these fusions initiate in early inflammation-associated prosta...

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Literature Corpus work: ff3e4e46-1bd6-5153-91a6-db2648ae6674
DOI: 10.1101/2020.07.27.224154

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