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Article

Molecular Diagnosis of Prostate Cancer: <i>PCA3</i> and <i>TMPRSS2:ERG</i> Gene Fusion

15 Jan 2012

Abstract excerpt

PURPOSE: Widespread prostate specific antigen screening together with the increase in the number of biopsy cores has led to increased prostate cancer incidence. Standard diagnostic tools still cannot unequivocally predict prostate cancer progression, which often results in a significant overtreatment rate. We present recent findings on PCA3 and TMPRSS:ERG fusion, and describe their clinical implications and...

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PMID: 22245323
DOI: 10.1016/j.juro.2011.10.133

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Related research

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Research trail→

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Molecular Diagnosis of Prostate Cancer: <i>PCA3</i> and <i>TMPRSS2:ERG</i> Gene FusionPMID 22245323Read ↗

PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer.Semantic proximity Read ↗

Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer.Semantic proximity Read ↗

<i>TMPRSS2:ERG</i> fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosisSemantic proximity Read ↗

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Performance of a single assay for both type III and type VI TMPRSS2:ERG fusions in noninvasive prediction of prostate biopsy outcome.Semantic proximity Read ↗

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signalingSemantic proximity Read ↗

PCA3 and TMPRSS2: ERG Urine Level as Diagnostic Biomarker of Prostate CancerSemantic proximity Read ↗

Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature ReviewSemantic proximity Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

<i>TMPRSS2</i> : <i>ERG</i> Fusion Identifies a Subgroup of Prostate Cancers with a Favorable PrognosisSemantic proximity Read ↗

Exploring therapeutic applications of PTEN, TMPRSS2:ERG fusion, and tumour molecular subtypes in prostate cancer managementSemantic proximity Read ↗

TMPRSS2-ERG fusion is frequently observed in gleason pattern 3 prostate cancer in a Canadian cohortSemantic proximity Read ↗

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