Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia ( PIN ) and intraductal carcinoma through retrograde glandular colonization

Abstract excerpt

Prostate cancer often manifests as morphologically distinct tumour foci and is frequently found adjacent to presumed precursor lesions such as high-grade prostatic intraepithelial neoplasia (HGPIN). While there is some evidence to suggest that these lesions can be related and exist on a pathological and morphological continuum, the precise clonal and temporal relationships between precursor lesions and invasive...

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