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Article

Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.

Anticancer research - 1 Sept 2012

Chow Anthony, Amemiya Yutaka, Sugar Linda, Nam Robert, Seth Arun

Abstract excerpt

BACKGROUND/AIM: Shortcomings of current methods of prostate cancer detection call for improved biomarkers. The transmembrane protease, serine 2:ets-related gene (TMPRSS2:ERG) gene fusion leads to the overexpression of ERG, an E-twenty six (ETS) family transcription factor, and is the most prevalent genetic lesion in prostate cancer, but its clinical utility remains unclear. MATERIALS AND METHODS: Two radical...

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Source

Identifiers

PMID: 22993300

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.PMID 22993300Read ↗

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signalingSemantic proximity Read ↗

The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate CancerSemantic proximity Read ↗

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.Semantic proximity Read ↗

The Discovery of Common Recurrent Transmembrane Protease Serine 2 (TMPRSS2)-Erythroblastosis Virus E26 Transforming Sequence (ETS) Gene Fusions in Prostate CancerSemantic proximity Read ↗

TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer ProgressionSemantic proximity Read ↗

Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.Semantic proximity Read ↗

The discovery and application of gene fusions in prostate cancer.Semantic proximity Read ↗

Exploring therapeutic applications of PTEN, TMPRSS2:ERG fusion, and tumour molecular subtypes in prostate cancer managementSemantic proximity Read ↗

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumorsSemantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

Comprehensive analysis of oncogenic signatures and consequent repurposed drugs in TMPRSS2:ERG fusion‐positive prostate cancerSemantic proximity Read ↗

Fusion in the ETS gene family and prostate cancerSemantic proximity Read ↗

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