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Article

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer

1 Dec 2016

Abstract excerpt

Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG genes, in combination with DNA breaks, facilitates the formation of TMPRSS2-ERG gene fusions. However, the origins of DNA breaks that underlie gene fusion formation in...

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PMID: 27926866
DOI: 10.1016/j.celrep.2016.11.019

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