Article

Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cells

2024-03-27

Abstract excerpt

Misfolded soluble trimeric species of superoxide dismutase 1 (SOD1) are associated with increased death in neuron-like cell models and greater disease severity in amyotrophic lateral sclerosis (ALS) patients compared to insoluble protein aggregates. The mechanism by which structurally independent SOD1 trimers cause cellular toxicity is unknown but may be a driver of disease pathology. Here, we uncovered the SOD1 t...

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Literature Corpus work: ff3d0c7e-2b9d-5ef5-8fc6-26837a4a9a15
DOI: 10.1101/2024.03.22.586186

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Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cellsDOI 10.1101/2024.03.22.586186Read

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