Article

The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlas

2026-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in superoxide dismutase 1 (SOD1) can disturb monomer folding and dimerization, ultimately leading to the development of amyotrophic lateral sclerosis (ALS). Genotype-phenotype knowledge of SOD1 monomer folding and dimerization is largely incomplete, impeding our ability to treat and understand SOD1-ALS. To address this issue, we performed multidimensional deep mutational scanning of ∼6...

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Literature Corpus work: 552fb6d0-566a-5d4e-ad40-07bed9898410
DOI: 10.64898/2026.07.15.738613

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