Article
Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord.
Brain : a journal of neurology - 14 Sept 2022
Trist Benjamin G, Genoud Sian, Roudeau Stéphane, Rookyard Alexander, Abdeen Amr, Cottam Veronica, Hare Dominic J, White Melanie, Altvater Jens, Fifita Jennifer A, Hogan Alison, Grima Natalie, Blair Ian P, Kysenius Kai, Crouch Peter J, Carmona Asuncion, Rufin Yann, Claverol Stéphane, Van Malderen Stijn, Falkenberg Gerald, Paterson David J, Smith Bradley, Troakes Claire, Vance Caroline, Shaw Christopher E, Al-Sarraj Safa, Cordwell Stuart, Halliday Glenda, Ortega Richard, Double Kay L
Abstract excerpt
Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in vitro and in transgenic animal models of amyotrophic lateral sclerosis. Detailed examination of the protein in disease-affected tissues from amyotrophic lateral sclerosis patients, however, remains scarce. We used histological, biochemical and analytical techniques to profile...
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