Article

GWAS-driven Pathway Analyses and Functional Validation Suggest <i>GLIS1</i> as a Susceptibility Gene for Mitral Valve Prolapse

2018-10-02

Abstract excerpt

Nonsyndromic Mitral valve prolapse (MVP) is a common degenerative valvular heart disease with severe health consequences, including arrhythmia, heart failure and sudden death. MVP is characterized by excess extracellular matrix secretion and cellular disorganization which leads to bulky valves that are unable to co-apt properly during ventricular systole. However, the triggering mechanisms of this process are most...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff38c865-b359-533a-baa1-690d1dc5790b
DOI: 10.1101/433268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GWAS-driven Pathway Analyses and Functional Validation Suggest <i>GLIS1</i> as a Susceptibility Gene for Mitral Valve ProlapseDOI 10.1101/433268Read

Genome-Wide Association Study–Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve ProlapseSemantic proximity Read

Genome-wide association meta-analysis supports genes involved in valve and cardiac development to associate with mitral valve prolapseSemantic proximity Read

Isolated prolapse of the posterior mitral valve leaflet: phenotypic refinement, heritability and genetic etiologySemantic proximity Read

Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.Semantic proximity Read

Genetic Architecture and Myocardial Fibrotic Remodeling in Mitral Valve ProlapseSemantic proximity Read

Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapseSemantic proximity Read

Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz Syndrome patients provides insights into genotype-phenotype relationsSemantic proximity Read

Genetic association analyses highlight biological pathways underlying mitral valve prolapseSemantic proximity Read

Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapseSemantic proximity Read

Genetics of syndromic and non-syndromic mitral valve prolapse.Semantic proximity Read

Characterization of LTBP2 mutation causing Mitral Valve ProlapseSemantic proximity Read

Characterization of genomic regulation profiles in human mitral valve whole tissue to annotate genetic risk loci for mitral valve prolapseSemantic proximity Read