Article

Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis

2022-05-19

Abstract excerpt

<title>Abstract</title> <bold>Background：</bold> Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear. <bold>Results: </bold>Here we found AR expression in RCC cells decreased in response to hypoxia, which might then lead to increase the cancer stem cells (CSC) phenotype thr...

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Literature Corpus work: febfb95d-6600-5fba-9cbc-4ed28e84367e
DOI: 10.21203/rs.3.rs-1632568/v1

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