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Article

SOX4 mediates cancer-associated fibroblasts related radioresistance in hepatocellular carcinoma

30 Jul 2025

Abstract excerpt

PURPOSE: Cancer-associated fibroblasts (CAFs), a crucial component of tumor microenvironment, play a critical role in tumorigenesis, progression, and conferring resistance to radiotherapy and chemotherapy. This study aimed to investigate the association between CAFs, CAF- related genes, and radioresistance in hepatocellular carcinoma (HCC). METHODS: CAFs were isolated from HCC tissues and subsequently utilized...

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PMID: 40736659
DOI: 10.1007/s13402-025-01088-z

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