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Article

Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2

22 Sept 2011

Abstract excerpt

CD133 has been recognized as a specific cell surface marker for cancer stem cells in various tumors, although its biological functions and transcriptional regulation remain unclear. We found that the CD133 expression level was up-regulated in the lung cancer cell lines N417, H358, and A549, when these cell lines were cultured under hypoxic conditions. Among the five promoters (P1-P5) of human CD133 gene loci, P1...

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Identifiers

PMID: 21947321
DOI: 10.3892/ijo.2011.1207

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