Article

Hypoxia-induced SZT2-AS1 is required for HIF-1 heterodimer formation and histone trimethylation in HCC cells under hypoxic microenvironment

2024-08-23

Abstract excerpt

<title>Abstract</title> <p>Hypoxic microenvironment plays a critical role in solid tumor growth, metastasis and angiogenesis. Hypoxia-inducible factors (HIFs), which are canonical transcription factors in response to hypoxia, are stabilized under hypoxia and they coordinate the process of hypoxia-induced gene expression leading to cancer progression. Increasing evidence has indicated that long noncoding RNAs (lnc...

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Literature Corpus work: 32b43ffd-ad80-5a20-80d2-6b6d1bf35ddc
DOI: 10.21203/rs.3.rs-4805397/v1

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