Article

Impaired MC3T3-E1 osteoblast differentiation triggered by oncogenic HRAS is rescued by the farnesyltransferase inhibitor Tipifarnib

2024-05-10

Abstract excerpt

<title>Abstract</title> <p>HRAS is a ubiquitously expressed protein and functions as a central regulator of cellular homeostasis. In somatic cells, mutations in this gene cause cancer, while germline mutations trigger a developmental disorder known as Costello syndrome (CS). Among numerous pathologies, adult CS patients develop osteoporosis. Previous studies implicated HRAS in bone homeostasis by controlling oste...

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Literature Corpus work: febeaad0-1495-5c5b-8d44-430b41221899
DOI: 10.21203/rs.3.rs-4353593/v1

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