Article

The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression

2022-09-19

Abstract excerpt

<h4>Background: </h4> Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents. In clinical treatments, the insensitivity of OS to conventional radiotherapy regimens significantly contributes to poor patient prognosis and survival. EXO1 is responsible for DNA repair pathways and telomere maintenance. Meanwhile, ATM and ATR are considered switches as they can regulate the expression of E...

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Literature Corpus work: eff2a0ad-f758-5b93-8dbb-4362498d55ca
DOI: 10.21203/rs.3.rs-1929572/v2

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