Article

Loss of DDRGK1 Impairs IRE1α UFMylation to Promote IRE1α Degradation, ER Stress and Apoptosis in ATDC5 Cells

2021-10-19

Abstract excerpt

<title>Abstract</title> <p>Background Spondyloepiphyseal dysplasia (SEMD) is a rare disease that is caused by the impaired development of cartilage. Although mutations in the <italic>DDRGK1 domain-containing</italic> (DDRGK1) gene have been found to be one of the causes of this disease, the underlying mechanism remains poorly understood. Here, we used the ATDC5 cell line to investigate the effects of the loss of...

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Literature Corpus work: f11e3521-6cd9-59f7-a273-09100c378b02
DOI: 10.21203/rs.3.rs-952431/v1

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