Article

The lncRNA HOTAIR/EZH2 interaction inhibitor AC1Q3QWB (AQB) attenuates fibrotic SSc skin tissue re-modelling

2026-06-16

Abstract excerpt

<h4>Objectives</h4> The long non-coding RNA HOTAIR has previously been shown to drive pro-fibrotic gene expression in SSc dermal fibroblasts through its ability to interact with EZH2. Targeting EZH2 enzymatic activity can reverse HOTAIR mediated pro-fibrotic gene expression but its many functions make it an undesirable therapeutic target for SSc. Recently inhibitors selectively targeting the HOTAIR/EZH2 interacti...

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Literature Corpus work: febaa666-a92d-509a-a0a1-9d897055ebd4
DOI: 10.64898/2026.06.12.730368

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