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Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma

12 Feb 2019

Abstract excerpt

Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) mediates trimethylation of lysine 27 of histone 3 (H3K27me3), which acts as a repressive epigenetic mark. Both EZH2 and H3K27me3 were elevated in SSc dermal fibroblasts and endothelial cells compared with healthy...

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PMID: 30755532
DOI: 10.1073/pnas.1813006116

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