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Article

Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH.

Annals of the rheumatic diseases - 1 Apr 2020

Wasson Christopher W, Abignano Giuseppina, Hermes Heidi, Malaab Maya, Ross Rebecca L, Jimenez Sergio A, Chang Howard Y, Feghali-Bostwick Carol A, Del Galdo Francesco

Abstract excerpt

BACKGROUND: Systemic sclerosis (SSc) is characterised by autoimmune activation, tissue and vascular fibrosis in the skin and internal organs. Tissue fibrosis is driven by myofibroblasts, that are known to maintain their phenotype in vitro, which is associated with epigenetically driven trimethylation of lysine 27 of histone 3 (H3K27me3). METHODS: Full-thickness skin biopsies were surgically obtained from the...

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Identifiers

PMID: 32041748
DOI: 10.1136/annrheumdis-2019-216542
PMCID: PMC7147169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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