Article

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect drug metabolism

2024-01-30

Abstract excerpt

<h4>Background: </h4> Transporters in the human liver play a major role in the metabolism of endo- and xenobiotics, as well as of pharmaceutical agents. Drugs and metabolites are extruded into the bile through the apical, canalicular membrane of the hepatocytes, while transporters in the basolateral membrane either promote the uptake or perform an extrusion of various compounds into the venous blood stream. Experi...

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Literature Corpus work: fe9cb1e8-ac5c-556d-9330-474954d191ce
DOI: 10.22541/au.170665133.30907950/v1

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