Article

Interactions of Anti-COVID-19 Drug Candidates With Hepatic Transporters May Cause Liver Toxicity and Affect Drug Metabolism

2021-04-08

Abstract excerpt

Transporters in the human liver play a major role in the metabolism of endo-and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake or expel various compounds into the venous blood stream. In the present work we have examined the in vitro interactions of some key repurposed drugs advocated to treat COVID-19 (lopinavir, ritonavir...

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Literature Corpus work: 4c5ced69-a2bf-533e-8366-7e8ae6ffa75a
DOI: 10.21203/rs.3.rs-382702/v1

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Interactions of Anti-COVID-19 Drug Candidates With Hepatic Transporters May Cause Liver Toxicity and Affect Drug MetabolismDOI 10.21203/rs.3.rs-382702/v1Read

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