Transporters and drug-drug interactions: important determinants of drug disposition and effects.

Abstract excerpt

Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine, liver, and kidney, which are critical for drug absorption and elimination. Moreover, they can be found in important blood-tissue barriers such as the blood-brain barrier. Inhibition or induction of drug transporters by coadministered drugs can alter...

Topics

• Absorption
• Animals
• Biological Transport
• Drug Interactions
• Food-Drug Interactions
• Genotype
• Humans
• Membrane Transport Modulators
• Membrane Transport Proteins
• Permeability
• Phenotype