Cell-intrinsic genetic regulation of peripheral memory-phenotype T cell frequencies

Abstract excerpt

Memory T and B lymphocyte numbers are thought to be regulated by recent and cumulative microbial exposures. We report here that memory-phenotype lymphocyte frequencies in B, CD4 and CD8 T-cells in 3-monthly serial bleeds from healthy young adult humans were relatively stable over a 1-year period, while recently activated -B and -CD4 T cell frequencies were not, suggesting that recent environmental exposures affect...

Topics

Open a Topic to create a Post that cites this publication.

• B-Lymphocytes
• Cell Differentiation
• Gene Expression
• Germinal Center
• Immunologic Memory
• Immunophenotyping
• Models, Biological
• Mutation

Identifiers and source

Literature Corpus work

fe7d270b-7f84-570c-9b63-e52346dea982

DOI

10.1101/355313