Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

16 Aug 2012

Abstract excerpt

Prominent immune alterations associated with aging include the loss of naïve T-cell numbers, diversity and function. While genetic contributors and mechanistic details in the aging process have been addressed in multiple studies, the role of environmental agents in immune aging remains incompletely understood. From the standpoint of environmental infectious agents, latent cytomegalovirus (CMV) infection has been...

Source

Identifiers

PMID: 22916012
DOI: 10.1371/journal.ppat.1002849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with AgingPMID 22916012Read ↗

Immune Senescence: Relative Contributions of Age and Cytomegalovirus InfectionSemantic proximity Read ↗

The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell RepertoireSemantic proximity Read ↗

Cytomegalovirus and immune senescence: culprit or innocent bystander?Semantic proximity Read ↗

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious DoseSemantic proximity Read ↗

Healthy Aging and Latent Infection with CMV Lead to Distinct Changes in CD8+ and CD4+ T-Cell Subsets in the ElderlySemantic proximity Read ↗

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by AgeSemantic proximity Read ↗

Age-related changes in CD8 T cell homeostasis and immunity to infection.Semantic proximity Read ↗

Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infectionSemantic proximity Read ↗

Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8<sup>+</sup>T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly PersonsSemantic proximity Read ↗

Mechanisms of immunosenescence: lessons from models of accelerated immune agingSemantic proximity Read ↗

Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalitiesSemantic proximity Read ↗

The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic SenescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.