Article

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function

2021-02-19

Abstract excerpt

During the human papillomavirus 16 (HPV16) life cycle, the E2 protein interacts with host factors to regulate viral transcription, replication and genome segregation/retention. Our understanding of host partner proteins and their roles in E2 functions remains incomplete. Here, we demonstrate that CK2 phosphorylation of E2 on serine 23 promotes interaction with TopBP1 in vitro and in vivo , and that E2 is phospho...

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Literature Corpus work: 51ffb531-6827-5921-8f67-a8f2433481e8
DOI: 10.1101/2021.02.17.431757

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