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PPAR-α agonist pirinixic acid alleviates periodontitis-induced AD-like pathology via suppression of the IRF7-IFN-β-IFITM3 axis in glial cells

2026-05-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Periodontitis is increasingly recognized as a contributing risk factor for Alzheimer's disease (AD). Our previous research demonstrated that periodontitis activates brain glial cells and upregulates the innate immune protein interferon-induced transmembrane protein 3 (IFITM3), leading to β-amyloid (Aβ) deposition. However, the underlying mechanisms remain unc...

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Literature Corpus work
fe456f39-d7fe-5f2d-b8f4-163d0405ecad
DOI
10.21203/rs.3.rs-9421608/v1
Open publication

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PPAR-α agonist pirinixic acid alleviates periodontitis-induced AD-like pathology via suppression of the IRF7-IFN-β-IFITM3 axis in glial cellsDOI 10.21203/rs.3.rs-9421608/v1
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