Article

mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

2020-05-16

Abstract excerpt

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion. The mammalian Target of Rapamycin (mTOR) signaling pathway is active in human oRG cells. Mutations in mTOR pathway genes are linked to a variety of neurodevelopmental disorders and malformations of cortical development. We find that dysr...

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Literature Corpus work: f529dfbc-786d-580b-b357-ee3c99b44a64
DOI: 10.1101/2020.05.14.095117

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