Article

Attractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body Weight

2026-01-16

Abstract excerpt

<h4>Summary</h4> The melanocortin 4 receptor (MC4R) plays a critical role in the central control of energy homeostasis and its disruption causes severe early onset obesity. The MC4R agonist Imcivree has been approved for the treatment of certain genetic obesity syndromes. Here we demonstrate that the membrane-spanning protein Attractin-like protein 1 (ATRNL1) directly interacts with MC4R to amplify its signaling...

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Literature Corpus work: f7183e6c-77a7-5203-b81a-cda0dce3d374
DOI: 10.64898/2026.01.12.26343722

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