Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

ACS chemical neuroscience - 20 Jul 2016

Swale Daniel R, Kurata Haruto, Kharade Sujay V, Sheehan Jonathan, Raphemot Rene, Voigtritter Karl R, Figueroa Eric E, Meiler Jens, Blobaum Anna L, Lindsley Craig W, Hopkins Corey R, Denton Jerod S

Abstract excerpt

The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) has recently emerged as a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. The pharmacological tools available for exploring the physiology and therapeutic potential of Kir7.1 have been limited to relatively weak and nonselective small-molecule inhibitors. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Patch-Clamp Techniques

Share to Potassium

Share to Potassium Channel Blockers

Share to Potassium Channels, Inwardly Rectifying

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 27184474
DOI: 10.1021/acschemneuro.6b00111
PMCID: PMC5131535

Genes

KCNJ13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.PMID 27184474Read ↗

Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.Semantic proximity Read ↗

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic StatesSemantic proximity Read ↗

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels.Semantic proximity Read ↗

KCNQ-Encoded Potassium Channels as Therapeutic Targets.Semantic proximity Read ↗

Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants.Semantic proximity Read ↗

Large-Scale Structure-Based Virtual Screening Identifies Diverse K <sub>Na</sub> 1.1 (KCNT1) Potassium Channel InhibitorsSemantic proximity Read ↗

The Shifting Landscape of K<sub>Atp</sub>Channelopathies and the Need for ‘Sharper’ TherapeuticsSemantic proximity Read ↗

The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control.Semantic proximity Read ↗

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down SyndromeSemantic proximity Read ↗

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants.Semantic proximity Read ↗

Functional screen for subtype specificity of voltage sensor-targeted Kv7 potentiators.Semantic proximity Read ↗

Kv1.3 in the spotlight for treating immune diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.