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Article

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

30 Apr 2020

Abstract excerpt

Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as well as periodic pandemics. A complete understanding of the virus pathogenesis and host factors involved in the viral lifecycle is crucial for developing novel therapeutic approaches. Sphingomyelin (SM) is the most abundant membrane sphingolipid. It preferentially associates with cholesterol to form distinct domains named...

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PMID: 32425895
DOI: 10.3389/fmicb.2020.00612

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