Article

Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease

2024-09-13

Abstract excerpt

<h4> Abstract </h4> COVID-19 remains a significant threat to public health globally. Infection in some susceptible individuals causes life-threatening acute lung injury (ALI/ARDS) and/or death. Human surfactant protein A (SP-A) is a C-type lectin expressed in the lung and other mucosal tissues, and it plays a critical role in host defense against various pathogens. The human SP-A genes ( SFTPA1 and SFTPA2 ) ar...

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Literature Corpus work: 34b9a2c1-9e63-5024-9947-ee1eabfc0a90
DOI: 10.1101/2024.09.11.612497

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