Article

The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism

2025-08-06

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial dysfunction and epigenetic alterations play critical roles in aging-related diseases, yet the molecular mechanisms linking mito-nuclear crosstalk to ovarian aging remain poorly understood. Here, single-cell transcriptome analysis of aging ovaries revealed senescence-associated hallmark alterations, including abnormally elevated mitochondrial metabolism, disrupted histone m...

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Literature Corpus work: 1dbf74fc-a6f1-5f19-9584-e12240a87875
DOI: 10.21203/rs.3.rs-7030863/v1

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