Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.

Nature communications - 20 Feb 2026

Li Jianing, Tanzillo Anthony F, Pizzirusso Giusy, Caccavano Adam, Chittajallu Ramesh, Sohn Mira, Abebe Daniel, Zhang Yajun, Pelkey Kenneth A, Dale Ryan K, McBain Chris J, Petros Timothy J

Abstract excerpt

Methylation of lysine 4 on histone H3 (H3K4) is enriched on active promoters and enhancers where it promotes gene activation. Disruption of H3K4 methylation is associated with numerous neurodevelopmental diseases (NDDs) that display intellectual disability and abnormal body growth. Here, we perturb H3K4 methylation in the medial ganglionic eminence (MGE) and hypothalamus, two brain regions associated with these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone-Lysine N-Methyltransferase
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothalamus

Share to Lysine

Share to Methylation

Share to Neurodevelopmental Disorders

Share to Prosencephalon

Share to Seizures

Source

Open in PubMed Open full text

Identifiers

PMID: 41720771
DOI: 10.1038/s41467-026-69248-9
PMCID: PMC13035845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.PMID 41720771Read ↗

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypesSemantic proximity Read ↗

Regulation of histone H3K4 methylation in brain development and disease.Semantic proximity Read ↗

Forebrain neuronal SMC3 regulates body weight and metabolic health partially through regulation of hypothalamic Melanocortin 4 receptorSemantic proximity Read ↗

Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophreniaSemantic proximity Read ↗

Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects.Semantic proximity Read ↗

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.Semantic proximity Read ↗

POGZ safeguards neuronal gene chromatin architecture and transcriptionSemantic proximity Read ↗

A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory NeuronsSemantic proximity Read ↗

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.Semantic proximity Read ↗

Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia.Semantic proximity Read ↗

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.Semantic proximity Read ↗

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.