Article

BBB pathophysiology independent delivery of siRNA in traumatic brain injury

2020-06-28

Abstract excerpt

Small interfering RNA (siRNA) represents a powerful strategy to mitigate the long-term sequelae of traumatic brain injury (TBI). However, poor permeability of siRNA across the blood brain barrier (BBB) poses a major hurdle. One approach to overcome this challenge involves treatment administration while the BBB is physically breached post-injury. However, this approach is only applicable to a subset of injuries wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe070c20-8458-5649-9660-a02149b951e2
DOI: 10.1101/2020.06.26.173393

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BBB pathophysiology independent delivery of siRNA in traumatic brain injuryDOI 10.1101/2020.06.26.173393Read

Intravenously Delivered Lipid Nanoparticles Access Acute Spinal Cord Injury via Disrupted VasculatureSemantic proximity Read

Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrierSemantic proximity Read

Advanced Therapies for Traumatic Central Nervous System Injury: Delivery Strategy Reinforced Efficient Microglial Manipulation.Semantic proximity Read

Biomaterials in Traumatic Brain Injury: Challenges and PerspectivesSemantic proximity Read

Mild traumatic brain injury/ concussion initiates an atypical astrocyte response caused by blood-brain barrier dysfunctionSemantic proximity Read

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous systemSemantic proximity Read

Minimally Invasive Neurosurgery in Traumatic Brain Injury: A Comprehensive Review of Neurological OutcomesSemantic proximity Read

What’s New in Spinal Cord Injury Management: A Narrative Review on the Emerging Role of NanotechnologySemantic proximity Read

Cracking the Blood–Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological TherapiesSemantic proximity Read

Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous systemSemantic proximity Read

Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic WindowSemantic proximity Read

Intranasal CRISPR- lipid nanoparticles targeting MAPK9 reduce neuroinflammation after traumatic brain injurySemantic proximity Read