Article

Intravenously Delivered Lipid Nanoparticles Access Acute Spinal Cord Injury via Disrupted Vasculature

2026-06-09

Abstract excerpt

Trauma to the spinal cord disrupts the blood-spinal cord barrier and triggers a secondary injury cascade characterized by inflammation and progressive neuronal and glial cell death. Therapeutic cytokines and growth factors have shown promise as a treatment in preclinical studies, though their clinical translation is limited by short protein half-lives and the need for invasive intraspinal administration. Lipid nan...

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Literature Corpus work: d1f9ea6b-8c30-566f-b039-059964efbb2f
DOI: 10.64898/2026.06.04.730155

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