Article

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank.

2021-11-10

Abstract excerpt

<p>The association between severe mental illness (SMI) and cardiovascular and metabolic disease (CMD) is poorly understood. PCSK9 is expressed in systems critical to both SMI and CMD and influences lipid homeostasis and brain function. We systematically investigated relationships between genetic variation within the PCSK9 locus and risk for both CMD and SMI. UK Biobank recruited ~500,000 volunteers and assessed a...

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Literature Corpus work: fdf9df11-11d2-5e80-a7c5-8f41ec8e02f2
DOI: 10.31234/osf.io/hktmu

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