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Article

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank.

European journal of human genetics : EJHG - 1 Dec 2022

Hay Rachel, Cullen Breda, Graham Nicholas, Lyall Donald M, Aman Alisha, Pell Jill P, Ward Joey, Smith Daniel J, Strawbridge Rona J

Abstract excerpt

The association between severe mental illness (SMI) and cardiovascular and metabolic disease (CMD) is poorly understood. PCSK9 is expressed in systems critical to both SMI and CMD and influences lipid homeostasis and brain function. We systematically investigated relationships between genetic variation within the PCSK9 locus and risk for both CMD and SMI. UK Biobank recruited ~500,000 volunteers and assessed a...

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Identifiers

PMID: 35501368
DOI: 10.1038/s41431-022-01107-9
PMCID: PMC9712543

Genes

PCSK9

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