Article
Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways.
American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2018
Livraghi-Butrico Alessandra, Wilkinson Kristen J, Volmer Allison S, Gilmore Rodney C, Rogers Troy D, Caldwell Ray A, Burns Kimberlie A, Esther Charles R, Mall Marcus A, Boucher Richard C, O'Neal Wanda K, Grubb Barbara R
Abstract excerpt
The epithelial Na+ channel (ENaC) regulates airway surface hydration. In mouse airways, ENaC is composed of three subunits, α, β, and γ, which are differentially expressed (α > β > γ). Airway-targeted overexpression of the β subunit results in Na+ hyperabsorption, causing airway surface dehydration, hyperconcentrated mucus with delayed clearance, lung inflammation, and perinatal mortality. Notably, mice...
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