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Article

Linking hnRNP Function to ALS and FTD Pathology

15 May 2018

Abstract excerpt

Following years of rapid progress identifying the genetic underpinnings of amyotrophic lateral sclerosis (ALS) and related diseases such as frontotemporal dementia (FTD), remarkable consistencies have emerged pointing to perturbed biology of heterogeneous nuclear ribonucleoproteins (hnRNPs) as a central driver of pathobiology. To varying extents these RNA-binding proteins are deposited in pathological inclusions...

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PMID: 29867335
DOI: 10.3389/fnins.2018.00326

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