Article
Generation of a WWTR1 mutation induced pluripotent stem cell line, MUSIi012-A-1, using CRISPR/Cas9.
Stem cell research - 1 Dec 2019
Lorthongpanich Chanchao, Jiamvoraphong Nittaya, Supakun Prapasri, Damkham Nattaya, Terbto Papussorn, Waeteekul Supaporn, U-Pratya Yaowalak, Laowtammathron Chuti, Issaragrisil Surapol
Abstract excerpt
WWTR1 or TAZ (WWTR1/TAZ) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway, which plays a pivotal role in regulating cell proliferation and anti-apoptosis. It has been shown in other cell types that WWTR1/TAZ plays a redundant role to its homolog YAP1. Using CRISPR/Cas9 gene editing, we established the WWTR1/TAZ-KO cell line, which features homozygous...
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